The Modified Hodge Test: Is it an appropriate method for detection of KPC enzyme or not?

from Iranian patients and the MHT test does not have a high sensitivity for BlaKPC identification in Iran and other countries unless it is confirmed by molecular methods. The Gram-negative bacilli such as Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii are the most important bacteria in nosocomial infection (13). To date, these bacteria are almost multidrug resistant (MDR) and show an outstanding ability to rapidly evolve resistance to newer antibiotics (14). For these isolates, therapeutic options are limited to antibacterial agents such as carbapenems (15), for these reasons, the accurate detection of carbapenemase-producing isolates is the first critical step in limiting and controlling the spread of the carbapenem of resistant isolates and report of a new mechanism of resistance to antibiotic cause a serious problem on the therapeutic choices existing for treatment of infections (12,16). Therefore, attempts to reduce spread of antibiotic resistance are based on a detailed knowledge of the mechanisms of resistance (16).